With the use of parametric and multi-criteria optimization digital tools, buildings can be designed to respond to various requirements. Recently, an expanded understanding of building performance acknowledges that all factors acting on buildings (climate, energies, information, human agents) are not static and fixed, but rather mutable and transient. This paper explores the possibilities of architectural design to benefit human condition, which encompasses physical and mental wellbeing, environmental quality of life during the Climate Change era. The first part of the paper defines the main factors (such as: lack of green nature and sunlight, noise and pollution) which are influencing the formation of psychological disorder in big cities. The negative impact of these factors is constantly increasing in the time of Climate Change progressing. The second part presents results of the research program undertaken at West Pomeranian University of Technology in Szczecin by author. The program (Climate Change Adapted Architecture and Structure) goes on to attempt to solve the problem through architectural design. This study highlights a social problem, such as mental well-being, resulting from urbanization or effects of the climate change, and serves as a useful background for further research on the possibilities of redefining sustainable and human friendly design).